İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı LncRNA’ların ve İnvazyonun Baskılanması

Objective: It was aimed to investigate the effects of boric acid on some lncRNAs and invasion in PANC-1 MIA PaCa-2 pancreatic cancer cells. Materials Methods: The cell viability were investigated using XTT test chambers, respectively. lncRNA H19 UCA1 expressions evaluated TCGA data. Its these genes determined by qRT-PCR analysis. Results: IC50 doses calculated as 14.25 mM cells 15.71 PaCa-2. data showed that elevated cancer. levels decreased with treatment. In addition, increased CDH1 TIMP1 both lines. However, it suppressed CDH2 expression. Boric TIMP2 TIMP3 expression test, significantly Conclusions: expressions, which found be high an anti-invasive effect changing are important invasion.